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Music Shawn Corey Carter (born December 4, 1969), better known by his stage name Jay-Z, is an American rapper and businessman. He is one of the most financially successful hip hop artists and entrepreneurs in America, having had a net worth of over $150 million in 2009, He has sold 40 million albums worldwide while receiving ten Grammy Awards for his musical work. He is considered by many to be one of the greatest MC’s of all-time. Along with his financial and musical success, Jay-Z is known for quarrelling with other artists in the rap industry, the most famous feud being between him and fellow New York rapper Nas, which was eventually settled in 2005. He married American R&B star Beyonc Knowles on April 4, 2008 On December 11th, 2009 Jay Z was ranked as the 10th best overall artist of 2000-2009 decade by Billboard Magazine. (Ranking as the 5th top solo male artist and as the 4th top rapper behind Eminem, Nelly, and 50 Cent). Jay-Z announced the North American dates for his 2010 BP3 Tour. The tour has begin on February 22 in Houston.Young Jeezy is scheduled to open all dates on the tour, tickets for which go on sale beginning November 13. The first leg of the tour is still under way, with dates in Fresno, California (Saturday), Los Angeles (Sunday), Austin, Texas (Tuesday) and Champaign, Illinois (November 12). The second leg will make stops in Dallas; New Orleans; Atlanta; Greensboro, North Carolina; Washington, D.C.; Boston; Pittsburgh; St. Louis; Indianapolis; Denver; Los Angeles; and more, according to the press release. Additional day of show and on-sale information will be announced shortly for stops in East Rutherford, New Jersey; Uniondale, New York; Atlantic City, New Jersey; and Detroit. Most of Concert tickets today are sold online only. Depending on the popularity of the band or the plays, the tickets are sold out well in advance. In some cases, you can even see Broadway tickets and other concert tickets selling out in a matter of hours, sometimes even minutes. About the Author: 相关的主题文章:

Business Script writing contest are definitely an inoculation for those that havent tasted success with their text. If you happen to be impatient as to highlight your selected script, this is amongst the most effective zones that you should begin with. Lots of individuals although having fantastic capabilities panic for making a passage with respect to Screenwriting end up believing in several hypotheses and superstition which aren’t in any respect correct. Defined criticism is very much what you should be looking for, if you are a wannabe script writer. Despite the fact that individuals are successful or unsuccessful in a script writing contest, Nevertheless, the amazing detail in which you acquire an appropriate opinion for your script that’s incredibly large. The best place to start looking for prominent and global screenwriting contests is of course the internet. With its global reach and potential to actually further upgrade ones potential talents, the world wide web is a definite one stop destination for all aspiring script writers. You should seek for web portals that can have found out an unrivalled standing while in this exact sector. Beyond just the script writing contest , the said portals have breakdown of full script in their site. It’d profit masses once you look at added screenplays to create a larger believing for it and as you are working for them, you might surely experience the distinction. The wide variety that you will witness in these screenwriting contests will surely sweep you off your feet additionally providing you with an enriching experience. It s very crucial you pick the right Screenwriting .petition to input your particular preferred written and published chunk, if you require to improve your chances being an award, that in fact also with script writing contest from masters as well as the leading & the most beneficial. Succeeding with the first prize will never be the only real important thing as youll be able to attract the judges attention; you should definitely draw big eyeballs within the industry. The entry you considered the weakest may take a winner’s ribbon merely since it evoked an appropriate response. Resulting in your content quite different in satisfied and magnificence shall also enhance your possibilities of triumphing the Screenwriting Opposition in question. Go for challenges depending on consequences and the results, if you deem you have a substantial audience, give everything you can. About the Author: 相关的主题文章:

Worldwide pediatric vaccine market has been growing rapidly over the last five years as it has doubled its market share in 2011 compared to 2005. The worldwide pediatrics vaccine market is expected to be more than US$ 23 Billion by 2015 growing with a single digit CAGR during 2012 2015. This incremental growth has been due to blockbuster vaccines (Prevnar7, Prevnar 13, Rotarix and Rotateq) sales in Billion of US$ which made a significant contribution. It is predicted that Pediatric proprietary vaccines will lead the segment with little less than 60% market share by 2015.The combinations & boosters and enhanced pediatric vaccines market are expected to show stagnant growth in future due to lower margins and the mature nature of these markets. Pneumococcal, DTP and Varicella together all these three vaccines control 55% of the market share in 2011. In number of cases Polio, Haemophiilus Influenzae Type B (HIB) and MMR cases have shown decline continuously from the year 2001 till 2011. Polio remains endemic merely in three countries and the good news is that India has not reported a single case from the past two years and on the verge of being called a polio free country. DTP are the most utilized vaccines in the pediatric vaccines market which contributed less than 10,000 Million doses in 2011. Pediatric Hepatitis and Polio vaccines are also mostly used vaccines which consumed more than 6,000 Million doses in 2011. In case of Rotavirus vaccine although the price of Rotavirus vaccine has declined but still its present prices are expensive than other pediatric vaccines. However despite all the impediments pediatric vaccines industry is expected to remain highly active in the future, fueled by the encouragement and financing from governments and other health organizations. Renub Research report titled "Pediatric Vaccines Market, Doses, Immunization, Cases and Forecast: Worldwide Analysis talks about the pediatric vaccines. The report provides information on all the Nine (9) Pediatric Vaccines Market, Doses, Immunization and Number of Cases by region in the world. This report covers in detail all aspects of past, present and future scenario. This report provides market landscape and market share information of the Pediatric Combinations & Booster, Pediatric Enhanced Combination and Pediatric Proprietary Vaccines Market. The report also entails major factors driving the pediatric vaccine market and challenges of pediatric vaccine market. Pediatric Vaccines Covered in this Report are as follows: Measles, Mumps & Rubella (MMR) Vaccines, Haemophilus Influenzae Type B (HIB) Vaccines, Polio Vaccines, Diphtheria, Tetanus & Pertussis (Combos) Vaccines, Pneumococcal Vaccines Rotavirus Vaccines, Hepatitis Pediatric Vaccines, Varicella/Chicken Pox Vaccines and Other Pediatric Vaccines All the Pediatric Vaccines in this Report have been Studied from Four View Points: Number of Cases Reported for all 9 Pediatric Diseases by Region from 2001 to 2011 Number of Doses Reported and Forecast for all 9 Pediatric Vaccine from 2005 to 2015 Immunization Coverage for all 9 Pediatric Vaccines and Forecast from 2005 to 2015 Market Size for all 9 Pediatric Vaccines and Forecast from 2005 to 2015 Key Topics Covered in the Report Worldwide Pediatric Vaccines Market and Forecast (2006 – 2015) Worldwide Pediatric Vaccines Market Share and Forecast (Sector wise) (2005 – 2015) Worldwide Pediatric Vaccines Market Share & Forecast (Disease wise) (2006 – 2015) By Sector (All 9) Pediatric Vaccines Market and Forecast (2005 – 2015) By Region – Pediatric Disease Cases (2001 2011) Pediatric Vaccines Doses and Forecast (2005 2015) Pediatric Vaccines Immunization Coverage and Forecast (2005 – 2015) All 9 Pediatric Vaccines Market and Forecast (2005 – 2015) Growth Drivers of Pediatric Vaccines Market Challenges of Pediatric Vaccines Market Data Sources This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by Renub Research team of industry experts. Primary sources include industry surveys and telephone interviews with industry experts. Secondary sources information and data has been collected from various printable and non-printable sources like search engines, News websites, Government Websites, Trade Journals, White papers, Government Agencies, Magazines, Newspapers, Trade associations, Books, Industry Portals, Industry Associations and access to more than 100 paid databases. Click here to view the report details: .www.renub.com/report/pediatric-vaccines-market-doses-immunization-cases-and-forecast-worldwide-analysis-86 For more information visit: .www.renub.com/ Contact Us Andy Hill Sr. Manager – Publisher Relation Sales & Marketing Div. Renub Research Email: [email protected] Phone: +1-678-302-0700 (USA) , +91-120-4219-822, +91-120-254-5750 (India) Web: ..renub../ 相关的主题文章:

Self-Improvement Ten thirty at night on Friday, December 26, two people died. An unhappy couple that had recently filed for divorce, Mary G. McNatt, age 69, and her husband, James Owen McNatt, age 73 were found dead, both at the hands of Mr. McNatt. Mrs. McNatt had reportedly told a friend previously that she was not happy with the marriage and actually afraid of her husband. Unfortunately, besides filing for divorce, nothing else was ever done to stop Mr. McNatt’s horrible behavior, and he ended up killing her by shooting her several times and then turned the gun on himself. This saddening incident should not have happened. Nothing like this should have to happen. It is all preventable. Front Sight Firearms Training Institute near Las Vegas, Nevada, can give you the self defense training you need in order to prevent things like this from happening. At the age of 69, Mrs. McNatt was alive and well, but not as strong as she was in her younger days. However, the instructors at Front Sight teach you how to use your body, instead of only physical strength, to help protect yourself. If we had to rely on physical strength alone many women, myself included, would be out of luck against a male attacker. But it does not have to be that way. There are ways to outsmart and disarm an attacker without using any strength at all – which means people who are considered to be "weak," "feeble" or "physically challenged" still have a fighting chance. This is good to know! Dr. Ignatius Piazza and his staff of highly trained instructors at Front Sight want us to learn these techniques and skills that could save our lives. Through a variety of courses, such as handgun training, rifle training, edged weapons training and martial arts training, students are taught how to protect themselves against armed and unarmed attackers, single and multiple attackers and attackers with different types of weapons. Maybe a course at Front Sight could have taught Mrs. McNatt how to disarm her husband. Women, as well as men, owe it to themselves to learn self defenses mechanisms. Front Sight is the best place to learn these skills. Faith Guta, a student of Front Sight said, "You’ll never receive this type of training and information anywhere else. No matter what your skill level may be when you arrive, you will leave better equipped to protect yourself and your loved ones." Do not put yourself at risk to be a victim, ESPECIALLY if there is already an immediate threat. Get yourself trained! Friends of Mrs. McNatt speak of what a wonderful person she was, how loved she was by so many people and how much she will be missed. They say she "never got the chance to have her happy ending." Give yourself a chance at a happy ending. Be able to protect yourself against an attacker. Get trained NOW. If you wait until tomorrow, it is sad to say that it might be too late. About the Author: 相关的主题文章:

Customer Service Do you sometimes wonder where your customers have gone? In a study by the International Customer Research Institute, individuals gave the following reasons for becoming "non-repeat" customers: * 1 percent died (makes you wonder how they responded) * 3 percent moved * 5 percent said friendships * 9 percent said competition * 14 percent were dissatisfied with the product * 68 percent cited an attitude of indifference by employees How many times do you think that employee attitude is communicated by phone? Very often the telephone is the first and only contact that people have with your organization. Make sure that this experience is the best you and your employees have to offer so that first-time callers become repeat customers. Smile when you answer the phone. Even if your hair is on fire or the last caller chewed you out, pause for a moment to put a smile on your face and in your voice. Believe it or not, people can hear you smiling through the phone. Answer the phone on the first ring, certainly no later than the third ring. If people have to wait through rings four and five, they begin to think that you have closed for the day, gone out of business or just don’t care. We live in a world that expects instant gratification. Be sure you meet your customers’ expectations. Ask permission before you put someone on hold. You may have multiple lines ringing and a line of people standing at your desk, but wait to hear the caller’s response. It is that person’s choice to hold or not. Try not to turn this move into a power play. When you come back on the line, thank the person for holding. If you have to ask the caller to continue to hold, offer to take a number and return the call. Transferring calls should be done with care. Before you connect the caller to someone else’s extension, make sure that person is in and able to help. There is nothing more frustrating than being transferred over and over again and having to retell the same story to a multitude of different people before finding the right one. Before you send the call to co-worker, give the caller that person’s name and number in case there is a disconnect. Better yet, tell the caller who you are and how to reach you if there is a problem. You will have an extremely satisfied customer. Always make an offer of help. It may not be your department, your issue or your job, but if it is the customer’s problem, you need to show concern. Never tell the caller " ‘I don’t know’" or "I can’t help you." The best response to a problem is a genuine "Let me see what I can do or who I can find to help you." You will win customers and influence people every time when you use good phone skills. (c) 2005, Lydia Ramsey. All rights reserved. Reprint rights granted so long as article and by-line are published intact and with all links made live. About the Author: Lydia Ramsey is a business etiquette expert, professional speaker, corporate trainer and author of MANNERS THAT SELL – ADDING THE POLISH THAT BUILDS PROFITS. She has been quoted or featured in The New York Times, Investors’ Business Daily, Entrepreneur, Inc., Real Simple and Woman’s Day. For more information about her programs, products and services, e-mail her at [email protected] or visit her web site Manners That Sell . Article Published On: 相关的主题文章:

Business Business cards are an essential marketing tool. Even in the age of digital communication, the importance of business cards remains intact. Business cards represent and are the face of a company and should therefore be designed with brand image and professional quality to stand out and create conversation. This article describes some of the essential guidelines to follow that help to get the look and feel to make a business card stand out. Business cards are used everywhere these days. Exchanged between potential clients, conversation starters within business meetings passed between friends and play a vital role at networking events. They represent the card holders basic information along with their companys brand. To help make an impression in any of these scenarios, the business card needs to stand out and create conversation. Following these essential guidelines can be vital in creating cards for any company representative looking to be remembered. Designing Business Cards Once a companys brand is developed its time to replicate the image onto business cards. Professional, trendy and unique designs along with assurance of vital information are the first steps in perfecting the business card. Selecting The Best Printing Company The final design is ready to print, now its time to choose an experienced online printer that offers professional, quality products, unique finishes, top-notch customer service and quick turnaround times all while offering competitive pricing. Making Business Cards Stand Out Choosing the finishing touch for the business card is key to helping it stand out. Look for unique finishes such as Spot UV , giving specified areas of a card a shiny gloss to stand out, Silk Lamination , ultra thick and durable with a sleek silky texture or Foil stamping , choosing from a wide a variety of foil colors. Rounded corners, plastic cards, UV Coating or various combinations of these effects can also add to the professional and unique fishing being sought after. Design, choosing a reputable online printing company and adding unique finishing touches can make the difference between a card that is put to the side and a card that is talked about. About the Author: The Author is associated with UV Cards. UV Cards offers high quality and unique business cards, brochures, door hangers, envelopes, greeting cards, letterhead , magnets, notepads, plastic cards , postcards, posters, presentation folders, stickers, sell sheets, table tents, vinyl banners, etc at competitive prices. Article Published On: http://www.articlesnatch.com – Business 相关的主题文章:

Lung-Mesothelioma-Asbestos An interesting study is called, Dickkopf-1 antagonizes Wnt signaling independent of -catenin in human Mesothelioma – Biochemical and Biophysical Research .munications – Volume 323, Issue 4, 29 October 2004, Pages 1246-1250 by Amie Y. Lee, Biao He, Liang You, Zhidong Xu, Julien Mazieres, Noemi Reguart, Iwao Mikami, Sonny Batra and David M. Jablons Here is an excerpt: Abstract – Dickkopf-1 (Dkk-1) is a secreted protein that acts as a potent inhibitor of the Wnt signal transduction pathway. It is thought that the antagonistic effect of Dkk-1 is specific to the canonical (Wnt/-catenin) pathway. In this study, we demonstrate that restoration of Dkk-1 expression suppresses cell growth and induces apoptotic cell death in -catenin-deficient mesothelioma cell lines H28 and MS-1. Furthermore, we found that a small-molecule inhibitor of JNK inhibited the apoptosis induced by Dkk-1 overexpression in these cells. Together, our data suggest that Dkk-1 may be able to antagonize Wnt signaling and exert its tumor suppressive effects through -catenin-independent non-canonical pathways. Another interesting study is called, Lysis of human malignant mesothelioma cells by natural killer (NK) and lymphokine-activated killer (LAK) cells. By Manning LS, Bowman RV, Darby SB, Robinson BW. – Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia. Am Rev Respir Dis. 1989 Jun;139(6):1369-74. Here is an excerpt: Abstract – Malignant mesothelioma is an aggressive tumor of the pleura for which, at present, there is no effective therapy. As interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells lyse many solid tissue malignancies that are unresponsive to conventional forms of therapy, the aim of this study was to evaluate the susceptibility of human malignant mesothelioma cells to lysis by natural killer (NK) and LAK cells. Using a 4-h 51Cr release assay, malignant mesothelioma cell lines grown from six different patients were found to be resistant to NK cell lysis (less than 10% lysis as .pared to 50 +/- 3% lysis of the standard NK-sensitive target, K562, p less than 0.001). These malignant mesothelioma cells were, however, susceptible to lysis by LAK cells (58 +/- 4% lysis, p less than 0.001 .pared to NK lysis). Similar results were seen using fresh mesothelioma cell targets (4 +/- 2% and 34 +/- 12% lysis for NK and LAK cells, respectively). Optimal LAK cell activation against these targets was achieved by incubating peripheral blood mononuclear cells (2 to 4 x 10(6)/ml) in culture medium containing 1,000 units/ml IL-2 for 3 to 14 days. The degree of LAK cell activation was dependent on the serum source used in culture, with autologous serum being more effective than pooled human AB serum or fetal calf serum at generating LAK cell activity in vitro (p less than 0.05). The results of this study demonstrate that although human malignant mesothelioma cells are resistant to NK cell lysis, IL-2-activated LAK cells effectively kill these targets. Another interesting study is called, Differentiation of Mesothelioma Cells Is Influenced by the Expression of Proteoglycans – Experimental Cell Research – Volume 258, Issue 1, 10 July 2000, Pages 12-22 by Katalin Dobraa, Michael Andngb, Alexandra Syrokouc, Nikos K. Karamanosc and Anders Hjerpea Here is an excerpt: Abstract – Malignant mesothelioma characteristically shows epithelial and/or sar.atous morphology, this phenotypic differentiation being correlated to the prognosis. The present study was undertaken to see whether proteoglycan (PG) expression influences mesothelioma differentiation. To assess this hypothesis, we studied a mesothelioma model, where the cells were induced to differentiate into epithelial or fibroblast-like morphology, mimicking the biphasic growth of this sar.a. Series of PGs were analyzed in parallel by semiquantitative reversed transcriptase polymerase chain reaction, showing increased expression of syndecan-2, syndecan-4, and hyaluronan synthase in the epithelial phenotype, whereas the fibroblast-like cells expressed more matrix PGs: versican, decorin, and biglycan. Western blotting confirms these differences and provides evidence of extensive shedding and rapid turnover of cell membrane PGs. Experimental down-regulation of the studied syndecans by antisense targeting resulted in a change in shape from polygonal to spindle-like morphology, while syndecan-1 and -4, but not syndecan-2, could be associated with cell aggregation, indicating distinct functions of different syndecans. The PG profile is thus closely associated with the morphology and biological behavior of tumor cells, mesotheliomas showing a different profile than true epithelial tumors. We all owe a debt of gratitude to these fine researchers for their work. If you found any of these excerpts helpful, please read the studies in their entirety. About the Author: 相关的主题文章:

Jewelry-Diamonds Bracelets circle your wrist giving it a delicate feminine look. Whether you want to go for the classic traditional look or sport a funky laidback style, you can do it with ease using the right kind of bracelets. There are so many e-stores from where you can buy bracelets online. Simple, efficient, and cost effective! When you buy gold bracelets online, you should definitely do background verification of the e-jewelry store. Read up on reviews about the online store and check the quality of the product purchased by customers in the past. Many online stores claim to deliver pure gold embedded with certified diamonds. If thats the case, you should get the certificates for the diamonds so that you can cross check its authenticity. After youre assured that the e-store is genuine and reliable, start browsing through the web pages and buy bracelets online. Now that youve decided on the e-store, you should decide on what style of bracelet you want to buy. Bracelets are available in plenty of styles, designs, and materials. If youre looking for an accessory to .plement your traditional outfit, you can buy gold bracelets online. Silver bracelets are a great option if you have a smaller budget. On the other hand, if you are looking to make an investment and have a larger budget, choose diamond bracelets. Pearl bracelets are a wardrobe staple. They go well with traditional as well as modern outfits. Bracelets with pearl hangings and other pretty charms will add a cute look to your ensemble. Leather bracelets are mostly preferred by the punk crowd. You can also get plastic and rubber bracelets. However, they may not last as long as a metal bracelet. Now that youve checked out the various materials bracelets are made from, lets take a look at the various designs theyre available in. The simplest bracelet is a large ring that can be easily slipped on the wrist. Floral design bracelets are a popular choice for anytime use. You can also choose bracelets with swan, bird, lotus, and other traditional designs. If youre planning to wear the bracelet every day, then you should go for a simple one without any hangings or charms. The hangings may get snagged on your outfit or keep digging into your wrists when youre working. Wearing bracelets can be more .fortable than bangles as they dont move up and down the arms like bangles. Plus, bracelets give you a chic sophisticated look that will match your formal office outfit. But, if youre looking for an accessory to perk up your party wear or ethnic dress, you can buy bracelets with plenty of hangings and charms. Go for jazzy, showy pieces that will glitter in the lights of the dance floor. So, what are you waiting for? Go buy gold bracelets online and show off your unique fashion sense. About the Author: 相关的主题文章: